Background
- 5-HTP is the precursor of the neurotransmitter serotonin. It is obtained commercially from the seeds of the plant Griffonia simplicifolia.
- 5-HTP has been suggested as a treatment for many conditions. There is some research to support the use of 5-HTP in treating cerebellar ataxia, headache, depression, psychiatric disorders, fibromyalgia, and as an appetite suppressant or weight-loss agent. There is not enough scientific evidence to support the use of 5-HTP for any other medical condition.
- 5-HTP may cause gastrointestinal disturbances, mood disturbances, seizure, or abnormal blood counts. Some reported side effects might result from contaminants in 5-HTP products.
References
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.
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View Abstract - Puttini PS, Caruso I. Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: a 90-day open study. J Int Med Res 1992;20(2):182-189.
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View Abstract - Thomson J, Rankin H, Ashcroft GW, et al. The treatment of depression in general practice: a comparison of L- tryptophan, amitriptyline, and a combination of L-tryptophan and amitriptyline with placebo. Psychol Med 1982;12(4):741-751.
View Abstract - Titus F, Davalos A, Alom J, et al. 5-Hydroxytryptophan versus methysergide in the prophylaxis of migraine. Randomized clinical trial. Eur Neurol 1986;25(5):327-329.
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