Background
- Tribulus terrestris has a long history of use for a variety of conditions. It has been suggested that it was used in ancient Greece and India as a physical rejuvenation tonic. In China, it is used as a component of therapy for conditions affecting the liver, kidney, cardiovascular system and immune systems. It has also been used in Eastern European folk medicine for increased muscle strength and sexual potency. Despite its history of use, there is limited human data available in order to evaluate its clinical effectiveness.
- Tribulus has been studied as a non-steroidal alternative to treatment of infertility. Although the results of the few studies done with the combination product Tribestan® are promising, more studies are needed in order to further evaluate its clinical effectiveness. Preliminary research with tribulus also suggests that it may be useful in treating coronary heart disease, but additional study is needed.
References
- Bedir E, Khan IA, Walker LA. Biologically active steroidal glycosides from Tribulus terrestris. Pharmazie 2002;57(7):491-493.
View Abstract - Brown GA, Vukovich MD, Martini ER, et al. Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men. Int J Vitam.Nutr.Res 2001;71(5):293-301.
View Abstract - Conrad J, Dinchev D, Klaiber I, et al. A novel furostanol saponin from Tribulus terrestris of Bulgarian origin. Fitoterapia 2004;75(2):117-122.
View Abstract - De Combarieu E, Fuzzati N, Lovati M, et al. Furostanol saponins from Tribulus terrestris. Fitoterapia 2003;74(6):583-591.
View Abstract - Deepak M, Dipankar G, Prashanth D, et al. Tribulosin and beta-sitosterol-D-glucoside, the anthelmintic principles of Tribulus terrestris. Phytomedicine. 2002;9(8):753-756.
View Abstract - Deng Y, Yang L, An SL. [Effect of Tribulus terrestris L decoction of different concentrations on tyrosinase activity and the proliferation of melanocytes]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2002;22(11):1017-1019.
View Abstract - Gauthaman K, Adaikan PG, Prasad RN. Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sci 8-9-2002;71(12):1385-1396.
View Abstract - Huang JW, Tan CH, Jiang SH, et al. Terrestrinins A and B, two new steroid saponins from Tribulus terrestris. J Asian Nat Prod Res 2003;5(4):285-290.
View Abstract - Jameel JK, Kneeshaw PJ, Rao VS, et al. Gynaecomastia and the plant product "Tribulis terrestris". Breast 2004;13(5):428-430.
View Abstract - Joshi VS, Parekh BB, Joshi MJ, et al. Inhibition of the growth of urinary calcium hydrogen phosphate dihydrate crystals with aqueous extracts of Tribulus terrestris and Bergenia ligulata. Urol.Res 2005;33(2):80-86.
View Abstract - Kohut ML, Thompson JR, Campbell J, et al. Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men. J Am Coll Nutr. 2003;22(5):363-371.
View Abstract - Li M, Qu W, Wang Y, Wan H, et al. [Hypoglycemic effect of saponin from Tribulus terrestris]. Zhong.Yao Cai. 2002;25(6):420-422.
View Abstract - Neychev VK, Mitev VI. The aphrodisiac herb Tribulus terrestris does not influence the androgen production in young men. J Ethnopharmacol. 2005; Oct 3;101(1-3):319-23
View Abstract - Sun B, Qu WJ, Zhang XL, et al. [Investigation on inhibitory and apoptosis-inducing effects of saponins from Tribulus terrestris on hepatoma cell line BEL-7402]. Zhongguo Zhong.Yao Za Zhi. 2004;29(7):681-684.
View Abstract - Sun B, Qu W, Bai Z. [The inhibitory effect of saponins from Tribulus terrestris on Bcap-37 breast cancer cell line in vitro]. Zhong.Yao Cai. 2003;26(2):104-106.
View Abstract