Background

• Members of the genus Bridelia are found throughout tropical and subtropical regions of the world, especially in Africa and Asia. Of the 60-70 members of this genus, the most commonly studied species are Bridelia ferruginea and Bridelia retusa.
• Traditionally, several Bridelia species are used to treat a variety of conditions, including dysentery, hemorrhoids, hemorrhage, heavy menstrual bleeding, leukorrhea, arthritis, diabetes, wounds, ulcers, poisoning, abdominal pain, and cardiovascular and gynecological conditions, and as a contraceptive. At this time, there is a lack of high-quality human trials in support of the use of Bridelia species for any indication.

References

1. Ajaiyeoba EO, Abiodun OO, Falade MO, et al. In vitro cytotoxicity studies of 20 plants used in Nigerian antimalarial ethnomedicine. Phytomedicine 2006;13(4):295-298. View Abstract
2. Gangoue-Pieboji J, Baurin S, Frere JM, et al. Screening of some medicinal plants from cameroon for beta-lactamase inhibitory activity. Phytother Res 2007;21(3):284-287. View Abstract
3. Jayasinghe L, Kumarihamy BM, Jayarathna KH, et al. Antifungal constituents of the stem bark of Bridelia retusa. Phytochemistry 2003;62(4):637-641. View Abstract
4. Kotigadde S, Jose S, Zachariah A, et al. Antibacterial activity of Bridelia
   scandens. J Commun Dis 2005;37(2):135-137. View Abstract
5. Lin J, Puckree T, Mvelase TP. Anti-diarrhoeal evaluation of some medicinal plants used by Zulu traditional healers. J Ethnopharmacol 2002;79(1):53-56. View Abstract
6. Magassouba FB, Diallo A, Kouyate M, et al. Ethnobotanical survey and antibacterial activity of some plants used in Guinean traditional medicine. J Ethnopharmacol 2007;114(1):44-53. View Abstract
7. Mehare ID, Hatapakki BL. Antiinflammatory activity of bark of Bridelia retusa spreng. Indian Journal of Pharmaceutical Sciences 2003;65(4):410-411.
8. Mostafa M, Nahar N, Mosihuzzaman M,et al. Phosphodiesterase-I inhibitor quinovic acid glycosides from Bridelia ndellensis. Nat Prod Res 2006;20(7):686-692. View Abstract
9. Mpiana PT, Tshibangu DS, Shetonde OM, et al. In vitro antidrepanocytary actvity (anti-sickle cell anemia) of some congolese plants. Phytomedicine 2007;14(2-3):192-195. View Abstract
10. Ngueyem TA, Brusotti G, Caccialanza G,et al. The genus Bridelia: a phytochemical and ethnopharmacological review. J Ethnopharmacol 2009;124(3):339-349. View Abstract
11. Ngueyem TA, Brusotti G, Marrubini G, et al. Validation of use of a traditional remedy from Bridelia grandis (Pierre ex Hutch) stem bark against oral Streptococci. J Ethnopharmacol 2008;120(1):13-16. View Abstract
12. Njamen D, Magne Ndé CB, Tanee Fomum Z, et al. Effects of the extracts of some tropical medicinal plants on estrogen inducible yeast and Ishikawa screens, and on ovariectomized Wistar rats. Pharmazie 2008;63(2):164-168. View Abstract
13. Olajide O, Okpako DT, Makinde JM. Anti-inflammatory properties of Bridelia
    ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. J Ethnopharmacol 2003;88(2-3):221-224. View Abstract
14. Sueyoshi E, Liu H, Matsunami K, et al. Bridelionosides A-F: Megastigmane glucosides from Bridelia
    glauca f. balansae. Phytochemistry 2006;67(22):2483-2493. View Abstract
15. Theophile D, Laure NE, Benoit NT, et al. Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae). Inflammopharmacology. 2006;14(1-2):42-47. View Abstract