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Canthaxanthin

Background

  • Canthaxanthin is a red and pink pigment that is naturally present in both plants and animals. The amount of canthaxanthin appearing on the skin depends on the amount of canthaxanthin consumed in the diet.
  • Like other carotenoids, canthaxanthin may have antioxidant effects.
  • Canthaxanthin collects in the second layer of skin, giving it a darker color and possibly protecting it from the sun.
  • Canthaxanthin may be sold as tanning pills that lack U.S. Food and Drug Administration (FDA) approval.
  • Studies show that canthaxanthin may help with cancer, skin pigmentation disorders, and vitiligo.

References

  1. Cauza E, Jansen M, Resch U, et al. Effects of LDL-immunoapheresis on plasma concentrations of vitamin E and carotenoids in patients with familial hypercholesterolemia. J Clin.Apher. 2004;19(4):174-179. View Abstract
  2. Hoffmann J, Linseisen J, Riedl J, et al. Dietary fiber reduces the antioxidative effect of a carotenoid and alpha-tocopherol mixture on LDL oxidation ex vivo in humans. Eur.J Nutr. 1999;38(6):278-285. View Abstract
  3. Ito Y, Suzuki K, Suzuki S, et al. Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants. Int.J Vitam.Nutr.Res 2002;72(4):237-250. View Abstract
  4. Ito Y, Wakai K, Suzuki, K., Tamakoshi, et al. Serum carotenoids and mortality from lung cancer: a case-control study nested in the Japan Collaborative Cohort (JACC) study. Cancer Sci. 2003;94(1):57-63. View Abstract
  5. Kompauer I, Heinrich J, Wolfram G, et al. Association of carotenoids, tocopherols and vitamin C in plasma with allergic rhinitis and allergic sensitisation in adults. Public Health Nutr. 2006;9(4):472-479. View Abstract
  6. Linseisen J, Hoffmann J, Riedl J, et al. Effect of a single oral dose of antioxidant mixture (vitamin E, carotenoids) on the formation of cholesterol oxidation products after ex vivo LDL oxidation in humans. Eur.J Med Res 2-21-1998;3(1-2):5-12. View Abstract
  7. Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann.N.Y.Acad.Sci. 12-31-1993;691:127-138. View Abstract
  8. Meraji S, Ziouzenkova O, Resch U, et al. Enhanced plasma level of lipid peroxidation in Iranians could be improved by antioxidants supplementation. Eur.J Clin.Nutr. 1997;51(5):318-325. View Abstract
  9. Paetau I, Chen H, Goh NM, et al. Interactions in the postprandial appearance of beta-carotene and canthaxanthin in plasma triacylglycerol-rich lipoproteins in humans. Am.J.Clin.Nutr. 1997;66(5):1133-1143. View Abstract
  10. Santamaria L and Bianchi-Santamaria A. Carotenoids in cancer chemoprevention and therapeutic interventions. J Nutr.Sci.Vitaminol.(Tokyo) 1992;Spec No:321-326. View Abstract
  11. Schmidt R, Hayn M, Fazekas F, et al. Magnetic resonance imaging white matter hyperintensities in clinically normal elderly individuals. Correlations with plasma concentrations of naturally occurring antioxidants. Stroke 1996;27(11):2043-2047. View Abstract
  12. Schmidt R, Hayn M, Reinhart B, et al. Plasma antioxidants and cognitive performance in middle-aged and older adults: results of the Austrian Stroke Prevention Study. J Am Geriatr.Soc 1998;46(11):1407-1410. View Abstract
  13. Schornagel IJ, Sigurdsson V, Nijhuis EH, et al. Decreased neutrophil skin infiltration after UVB exposure in patients with polymorphous light eruption. J Invest Dermatol 2004;123(1):202-206. View Abstract
  14. Suzuki K, Inoue T, Hioki R, et al. Association of abdominal obesity with decreased serum levels of carotenoids in a healthy Japanese population. Clin.Nutr. 2006;25(5):780-789. View Abstract
  15. White WS, Stacewicz-Sapuntzakis M, Erdman, JW, Jr., et al. Pharmacokinetics of beta-carotene and canthaxanthin after ingestion of individual and combined doses by human subjects. J.Am.Coll.Nutr. 1994;13(6):665-671. View Abstract
Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.