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Chelation therapy

Background

  • EDTA chelation became well known during the 1950s when it was proposed as a method to cleanse the blood and blood vessel walls of toxins and minerals. The technique involves infusing a chemical called ethylene diamine tetraacetic acid (EDTA) into the blood. The therapy is sometimes given by mouth and occasionally, other chemicals may be used.
  • Initially, chelation was used to treat heavy metal poisoning. Some observers felt that other benefits occurred in patients receiving this therapy. Currently, chelation practitioners may recommended this treatment for diabetes, for clogged arteries in the heart or legs (called peripheral vascular disease), and for many other conditions. Twenty or more sessions may be recommended and can cost several thousand dollars.

References

  • Anand A, Evans MF. Does chelation therapy work for ischemic heart disease? Can Fam Physician 2003;49:307-309.
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  • Anderson TJ, Hubacek J, Wyse, DG, et al. Effect of chelation therapy on endothelial function in patients with coronary artery disease: PATCH substudy. J Am Coll Cardiol 2-5-2003;41(3):420-425.
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  • Bell SA. Chelation therapy for patients with ischemic heart disease. JAMA 4-24-2002;287(16):2077-2078.
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  • Chappell LT, Stahl JP, Evans R. EDTA chelation therapy for vascular disease: a meta-analysis using unpublished data. J Adv Med 1994;7:131-142.
  • Ernst E. Chelation therapy for coronary heart disease: an overview of all clinical investigations. Am Heart J 2000;140(1):139-141.
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  • Grebe HB, Gregory PJ. Inhibition of warfarin anticoagulation associated with chelation therapy. Pharmacotherapy 2002;22(8):1067-1069.
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  • Huynh-Do U. [Gout nephropathy--ghost or reality?]. Ther Umsch 2004;61(9):567-569.
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  • Knudtson ML, Wyse DG, Galbraith PD, et al. Chelation therapy for ischemic heart disease: a randomized controlled trial. JAMA 1-23-2002;287(4):481-486.
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  • Morgan BW, Kori S, Thomas JD. Adverse effects in 5 patients receiving EDTA at an outpatient chelation clinic. Vet Hum Toxicol 2002;44(5):274-276.
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  • Najjar DM, Cohen EJ, Rapuano CJ, et al. EDTA chelation for calcific band keratopathy: results and long-term follow-up. Am J Ophthalmol 2004;137(6):1056-1064.
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  • Quan H, Ghali WA, Verhoef MJ, et al. Use of chelation therapy after coronary angiography. Am J Med 12-15-2001;111(9):686-691.
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  • Schnabel P, Erdmann E. [Is chelation therapy in coronary heart disease useful?]. Dtsch Med Wochenschr 8-16-2002;127(33):1715.
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  • Strassberg D. Chelation therapy for patients with ischemic heart disease. JAMA 4-24-2002;287(16):2077-2078.
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  • Villarruz MV, Dans AL, Tan FN. Chelation therapy for atherosclerotic cardiovascular disease [protocol]. Cochrane Database of Systematic Reviews 2002;(4):CD002785.
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  • Wong SS, Nahin RL. National Center for Complementary and Alternative Medicine perspectives for complementary and alternative medicine research in cardiovascular diseases. Cardiol Rev 2003;11(2):94-98.
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Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.