Background

• Cissus quadrangularis is a vine native to Africa, Southeast Asia, and India. Historically, Cissus quadrangularis was used for bone health, pain relief, and stomach conditions.
• Traditionally, parts of the Cissus plant have been mashed, roasted, juiced, pulped, or cooked before application. In modern times, Cissus quadrangularis has been taken as a powder or capsule.
• Cissus quadrangularis has been studied for its potential to treat osteoporosis and obesity. Additional research on these topics is needed.

References

1. Dhatrak Sarang, Thawani Vijay Gharpure Kunda Apte Indrayani Masand Anil Hingorani Lal and Khiyani Raj. Effect of Herbal Combination in Low Bone Mass Density Patients. International Journal of Drug Discovery and Technology 2011;2(1):9-14.
2. Hasani-Ranjbar, S., Nayebi, N., Larijani, B., and Abdollahi, M. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World J Gastroenterol 7-7-2009;15(25):3073-3085. View Abstract
3. Oben, J. E., Enyegue, D. M., Fomekong, G. I., Soukontoua, Y. B., and Agbor, G. A. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress. Lipids Health Dis 2007;6:4. View Abstract
4. Oben, J. E., Ngondi, J. L., Momo, C. N., Agbor, G. A., and Sobgui, C. S. The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12. View Abstract
5. Oben, J., Kuate, D., Agbor, G., Momo, C., and Talla, X. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006;5:24. View Abstract
6. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai. 2010;93(12):1360-1367. View Abstract
7. Thawani VR, Kimmatkar N Hingorani LL Khiyani RM. Effect of herbal combination containing cissus quadrangularis in fracture healing. The Antiseptic 2002;99(9):345-347.