Background

• Citicoline was first used to treat stroke. Citicoline may help treat diseases of the nerves and brain. Citicoline may help prevent the release of harmful chemicals in the body after decreased blood flow to the brain.
• Citicoline has been studied as a treatment for disorders associated with aging, including memory loss, glaucoma (increased eye pressure), and problems with nerve function.
• Citicoline is used in Europe and Japan for stroke, head injury, and other nerve diseases.

References

1. Brown ES, Gorman A R, Hynan LS. A randomized, placebo-controlled trial of citicholine add-on therapy in outpatients with bipolar disorder and cocaine dependence. J Clin Psychopharmacol 2007;27(5):498-502. View Abstract
2. Conant R, Schauss A. G. Therapeutic applications of citicoline for stroke and cognitive dysfunction in the elderly: a review of the literature. Altern Med Rev 2004;9(1):17-31. View Abstract
3. Clark WM, Wechsler LR, Sabounjian LA, et al. A phase III randomized efficacy trial of 2000 mg citicoline in acute ischemic stroke patients. Neurology 11-13-2001;57(9):1595-1602. View Abstract
4. Clark WM, Williams BJ, Selzer KA, et al. A randomized efficacy trial of citicoline in patients with acute ischemic stroke. Stroke. 1999;30(12):2592-2597. View Abstract
5. Diaz V, Rodriguez J, Barrientos P, et al. Use of procholinergics in the prevention of postoperative delirium in hip fracture surgery in the elderly. A randomized controlled trial]. Rev Neurol 10-16-2001;33(8):716-719. View Abstract
6. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2004;(2):CD000269. View Abstract
7. Iranmanesh F, Vakilian A. Efficiency of citicoline in increasing muscular strength of patients with nontraumatic cerebral hemorrhage: a double-blind randomized clinical trial. J Stroke Cerebrovasc Dis 2008;17(3):153-155. View Abstract
8. Jambou R, El-Assaad F, Combes, V, et al. Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. Int J Biochem Cell Biol 2009;41(7):1467-1470. View Abstract
9. Kalisvaart KJ, de Jonghe JF, Bogaards MJ, et al. Haloperidol prophylaxis for elderly hip-surgery patients at risk for delirium: a randomized placebo-controlled study. J Am Geriatr Soc 2005;53(10):1658-1666. View Abstract
10. Kidd PM. Integrated brain restoration after ischemic stroke--medical management, risk factors, nutrients, and other interventions for managing inflammation and enhancing brain plasticity. Altern Med Rev 2009;14(1):14-35. View Abstract
11. Marcantonio ER, Flacker JM, Wright RJ, et al. Reducing delirium after hip fracture: a randomized trial. J Am Geriatr Soc 2001;49(5):516-522. View Abstract
12. Parisi V, Coppola G, Centofanti M. Evidence of the neuroprotective role of citicoline in glaucoma patients. Prog Brain Res 2008;173:541-554. View Abstract
13. Saver JL. Citicoline: update on a promising and widely available agent for neuroprotection and neurorepair. Rev.Neurol.Dis. 2008;5(4):167-177. View Abstract
14. Secades JJ, Lorenzo J. L. Citicoline: pharmacological and clinical review, 2006 update. Methods.Find Exp Clin Pharmacol 2006;28 Suppl B:1-56. View Abstract
15. Secades JJ, Alvarez-Sabin J, Rubio F, et al. Cerebrovasc Dis 2006;21(5-6):380-385. View Abstract
16. Virno M, Pecori-Giraldi J, Liguori A, et al. The protective effect of citicoline on the progression of the perimetric defects in glaucomatous patients (perimetric study with a 10-year follow-up). Acta Ophthalmol.Scand.Suppl 2000;(232):56-57. View Abstract