Background

• Galega officinalis, commonly known as goat's rue, French lilac, Italian fitch, or professor-weed, is a bitter and strong-smelling herb that grows in the Middle East, southern Europe, and western Asia.
• Although now considered a weed, goat's rue was introduced into the United States in 1891 as forage for livestock.
• Goat's rue has been traditionally used to increase breast milk production and treat diabetes. Goat's rue may also help control blood sugar and promote weight loss.
• Although not well studied in humans, goat's rue may interact with medicines taken to reduce blood sugar or reduce the risk of bleeding.
• Galegine, a Galega extract, led to the development of the only approved biguanide antidiabetic drug, metformin.

References

1. Atanasov AT, Chorbanov BP, and Dimitrov BD. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. Folia Med.(Plovdiv.) 2002;44(1-2):45-49. View Abstract
2. Atanasov AT and Spasov V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. View Abstract
3. Atanasov AT and Tchorbanov B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234. View Abstract
4. Atanasov AT and Tchorbanov BJ. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
5. Bailey CJ and Day C. Metformin: its botanical background. Pract Diab Int 2004;21(3):115-117.
6. Barger G and White FD. Galuteolin, a New Glucoside from Galega Officinalis. Biochem.J 1923;17(6):836-838. View Abstract
7. Cavaliere C. Glucophage: Diabetic drug based on traditional herb celebrates 50 years of use. HerbalGram 2008;76:44-49.
8. Champavier Y, Allais DP, Chulia AJ, and Kaouadji M. Acetylated and non-acetylated flavonol triglycosides from Galega officinalis. Chem.Pharm Bull.(Tokyo) 2000;48(2):281-282. View Abstract
9. Hadden DR. Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection. J R.Coll.Physicians Edinb. 2005;35(3):258-260. View Abstract
10. Keeler RF, Baker DC, and Evans JO. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. 1988;30(5):420-423. View Abstract
11. Lemus I, Garcia R, Delvillar E, and Knop G. Hypoglycaemic activity of four plants used in Chilean popular medicine. Phytother.Res. 1999;13(2):91-94. View Abstract
12. Mooney MH, Fogarty S, Stevenson C, Gallagher AM, Palit P, Hawley SA, Hardie DG, Coxon GD, Waigh RD, Tate RJ, Harvey AL, and Furman BL. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br.J Pharmacol. 2008;153(8):1669-1677. View Abstract
13. Neef H, Augustijns P, Declercq P, Declerck PJ, and Laekeman G. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells. Pharmaceutical and Pharmacological Letters 1996;6:86-89.
14. Palit P, Furman BL, and Gray AI. Novel weight-reducing activity of Galega officinalis in mice. J Pharm Pharmacol. 1999;51(11):1313-1319. View Abstract
15. Petricic J and Kalodera Z. Galegin in the goat's rue herb: toxicity, antidiabetic activity and content determination. Acta Pharm Jugosl 1982;32:219-223.