Background

• L-glutamine is a nonessential amino acid (i.e., the human body can synthesize it) found mainly in skeletal muscle. Glutamine plays an important role in many functions of the body, including acid-base balance, nitrogen supply, and formation of DNA, protein, and other nutrients. A typical dietary intake is 5-10 grams daily, coming from common dietary animal and plant protein sources. In certain situations, such as in severe illness or trauma, the body may require higher levels of glutamine. Glutamine has been commonly studied in postsurgical, trauma, critically ill, burn, very-low-birthweight, and transplant patients, as well as for reducing side effects of chemotherapy, radiation therapy, and HIV medications. Glutamine is also commonly used to improve general immune system health and for exercise performance enhancement.
• Some well-designed studies support the use of glutamine as part of parenteral nutrition (nutrition delivered by injection into a vein or muscle) in postsurgical, burn, or ill patients. Further research in patients with malnutrition, digestive concerns, or other illnesses is needed.

References

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