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ingredients

Indiantobacco

Background

  • Lobelia, also known as Indian tobacco, is a genus in the plant family Campanulaceae. Lobeline, a chemical in lobelia, has been used to induce emesis (vomiting) and improve lung conditions like asthma and bronchitis. Lobelia has been nicknamed "pukeweed" for its vomit-inducing effects.
  • According to some research, lobeline has similar effects to nicotine, and it has been added to smoking cessation aids. It is unclear whether lobeline is effective for this use.
  • All parts of the lobelia plant are potentially toxic. Eating lobelia has caused death in cattle and horses. It is not listed on the U.S. Food & Drug Administration (FDA) Generally Recognized as Safe (GRAS) list, due to possible adverse effects, including respiratory stimulation (increased breathing), low blood pressure, and even death.

References

  1. Brown NM, Trizna Z, Pathak S. Clastogenic interactions between lobeline sulfate and ethyl alcohol: a cytogenetic study. Anticancer Res 1992;12(5):1467-1469. View Abstract
  2. Davison GC, Rosen RC. Lobeline and reduction of cigarette smoking. Psychol Rep 1972;31(2):443-456. View Abstract
  3. Dwoskin LP, Crooks PA. A novel mechanism of action and potential use for lobeline as a treatment for psychostimulant abuse. Biochem Pharmacol 2002;63(2):89-98. View Abstract
  4. Grewal RS, Lufc, Allmark MG. The release of posterior pituitary hormone in the rat by nicotine and lobeline. J Pharmacol Exp Ther 1962;135:84-88. View Abstract
  5. Ikeda K, Takahashi M, Nishida M, et al. Homonojirimycin analogues and their glucosides from Lobelia sessilifolia and Adenophora spp. (Campanulaceae). Carbohydr Res 2000;323(1-4):73-80. View Abstract
  6. Mazur LJ, De Ybarrondo L, Miller J, et al. Use of alternative and complementary therapies for pediatric asthma. Tex Med 2001;97(6):64-68. View Abstract
  7. McChargue DE, Collins FL, Jr., Cohen LM. Effect of non-nicotinic moist snuff replacement and lobeline on withdrawal symptoms during 48-h smokeless tobacco deprivation. Nicotine Tob Res 2002;4(2):195-200. View Abstract
  8. Miller DK, Crooks PA, Dwoskin LP. Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes. Neuropharmacology 2000;39(13):2654-2662. View Abstract
  9. Plakun AL, Ambrus J, Bross I, et al. Clinical factors in smoking withdrawal: preliminary report. Am J Public Health Nations Health 1966;56(3):434-441. View Abstract
  10. Stead LF, Hughes JR. Lobeline for smoking cessation. Cochrane Database Syst Rev 2000;(2):CD000124. View Abstract
  11. Subarnas A, Oshima Y, Sidik, et al. An antidepressant principle of Lobelia inflata L. (Campanulaceae). J Pharm.Sci. 1992;81(7):620-621. View Abstract
  12. Subarnas A, Tadano T, Nakahata N, et al. A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test. Life Sci 1993;52(3):289-296. View Abstract
  13. Subarnas A, Tadano T, Oshima Y, et al. Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves. J Pharm Pharmacol 1993;45(6):545-550. View Abstract
  14. Teng L, Crooks PA, Dwoskin LP. Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles: comparison with d-amphetamine. J Neurochem 1998;71(1):258-265. View Abstract
  15. Tian Q, Zhao D, Zhang J, et al. Investigation on inhibition of biological effects of endothelin. Sci China C Life Sci 1996;39(2):207-216. View Abstract
Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.