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Mangosteen (Garcinia mangostana)

Background

  • Mangosteen is a tropical tree native to Asia. In southeast Asian traditional medicine, such as Thai indigenous medicine, the fruit hulls (pericarp) or rinds of mangosteen are used for many different conditions, including skin infections, wounds, and diarrhea. Other plant parts, such as the leaves, bark, and fruit pulp, are also used in traditional medicine.
  • Mangosteen contains many active phytochemicals. One set of compounds, the prenylated xanthones, has been well-researched; there are several laboratory studies showing antibacterial, anti-cancer, and anti-inflammatory effects, and studies in animals showing anti-inflammatory effects. However, currently there are no high-quality human trials supporting the effectiveness of mangosteen for any indication.

References

  • Chomnawang MT, Surassmo S, Nukoolkarn VS, et al. Antimicrobial effects of Thai medicinal plants against acne-inducing bacteria. J Ethnopharmacol. 10-3-2005;101(1-3):330-333.
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  • Ho CK, Huang YL, Chen CC. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta Med 2002;68(11):975-979.
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  • Jung HA, Su BN, Keller WJ, et al. Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen). J Agric.Food Chem 3-22-2006;54(6):2077-2082.
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  • Matsumoto K, Akao Y, Kobayashi E, et al. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines. J Nat Prod 2003;66(8):1124-1127.
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  • Matsumoto K, Akao Y, Yi H, et al. Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells. Bioorg.Med Chem 11-15-2004;12(22):5799-5806.
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  • Moongkarndi P, Kosem N, Kaslungka S, et al. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004;90(1):161-166.
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  • Moongkarndi P, Kosem N, Luanratana O, et al. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia 2004;75(3-4):375-377.
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  • Nakatani K, Atsumi M, Arakawa T, et al. Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002;25(9):1137-1141.
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  • Nakatani K, Yamakuni T, Kondo N, et al. gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol.Pharmacol. 2004;66(3):667-674.
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  • Nguyen LH, Venkatraman G, Sim KY, et al. Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana. Phytochemistry 2005;66(14):1718-1723.
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  • Sakagami Y, Iinuma M, Piyasena KG, et al. Antibacterial activity of alpha-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Phytomedicine. 2005;12(3):203-208.
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  • Sato A, Fujiwara H, Oku H, et al. Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells. J Pharmacol.Sci 2004;95(1):33-40.
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  • Suksamrarn S, Komutiban O, Ratananukul P, et al. Cytotoxic prenylated xanthones from the young fruit of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2006;54(3):301-305.
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  • Suksamrarn S, Suwannapoch N, Phakhodee W, et al. Antimycobacterial activity of prenylated xanthones from the fruits of Garcinia mangostana. Chem.Pharm Bull.(Tokyo) 2003;51(7):857-859.
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  • Voravuthikunchai SP, Kitpipit L. Activity of medicinal plant extracts against hospital isolates of methicillin-resistant Staphylococcus aureus. Clin Microbiol.Infect. 2005;11(6):510-512.
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Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.