Background
- Nutmeg and mace are two commonly used spices that come from the same tree, Myristica fragrans. Nutmeg is made from the seed of the tree and mace from the seed covering. Papuan nutmeg (Myristica argentea), Bombay nutmeg (Myristica malabarica), and Jamaican nutmeg (Monodora myristica) are not true nutmeg.
- Nutmeg is best known for its use in food. It is used in cooking around the world. Other traditional uses of nutmeg include treatment of diarrhea, mouth sores, and insomnia.
- Nutmeg also has a history of abuse as a recreational drug. Severe nutmeg poisoning and, in some cases, death have been reported with consumption of very large amounts of nutmeg.
References
- Chirathaworn C, Kongcharoensuntorn W, Dechdoungchan T, et al. Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. J Med Assoc Thai 2007;90(11):2422-8.
View Abstract - Demetriades AK, Wallman PD, McGuiness A, et al. Low cost, high risk: accidental nutmeg intoxication. Emerg Med J 2005;22(3):223-5.
View Abstract - Dorman HJ, Deans SG. Antimicrobial agents from plants: antibacterial activity of plant volatile oils. J Appl Microbiol 2000;88(2):308-16.
View Abstract - Duan L, Tao HW, Hao XJ, et al. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans. Planta Med 2009;75(11):1241-5.
View Abstract - Firouzi R, Shekarforoush SS, Nazer AH, et al. Effects of essential oils of oregano and nutmeg on growth and survival of Yersinia enterocolitica and Listeria monocytogenes in barbecued chicken. J Food Prot 2007;70(11):2626-30.
View Abstract - Forrester MB. Nutmeg intoxication in Texas, 1998-2004. Hum Exp Toxicol 2005;24(11):563-6.
View Abstract - Gonçalves JL, Lopes RC, Oliveira DB, et al. In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea. J Ethnopharmacol 2005;99(3):403-7.
View Abstract - Hallström H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5(5):186-92.
View Abstract - Kwon HS, Kim MJ, Jeong HJ, et al. Low-density lipoprotein (LDL)-antioxidant lignans from Myristica fragrans seeds. Bioorg Med Chem Lett 2008;18(1):194-8.
View Abstract - Misharina TA, Terenina MB, Krikunova NI. [Antioxidant properties of essential oils]. Prikl Biokhim Mikrobiol 2009;45(6):710-6.
View Abstract - Noiles K, Pratt M. Contact dermatitis to Vicks VapoRub. Dermatitis 2010;21(3):167-9.
View Abstract - Nguyen PH, Le TV, Kang HW, et al. AMP-activated protein kinase (AMPK) activators from Myristica fragrans (nutmeg) and their anti-obesity effect. Bioorg Med Chem Lett 2010;20(14):4128-31.
View Abstract - Rani P, Khullar N. Antimicrobial evaluation of some medicinal plants for their anti-enteric potential against multi-drug resistant Salmonella typhi. Phytother Res 2004;18(8):670-3.
View Abstract - Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol 1994;42(2):117-24.
View Abstract - Yang XW, Huang X, Ahmat M.[New neolignan from seed of Myristica fragrans]. Zhongguo Zhong Yao Za Zhi 2008;33(4):397-402.
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