Background

• Phlorizin, also known as phloridzin, is a compound found in several fruit trees, including apple and cherry, and the bark of pear trees.
• Experts have suggested that phlorizin may block glucose (sugar) absorption from the intestines and increase glucose loss in the urine.
• Phlorizin and its analogs (similar chemical compounds) are being investigated for the treatment of diabetes, obesity, and stress hyperglycemia (high blood sugar levels). At this time, clinical studies investigating effects of phlorizin are lacking.

References

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4. Bradford, B. J. and Allen, M. S. Phlorizin administration increases hepatic gluconeogenic enzyme mRNA abundance but not feed intake in late-lactation dairy cows. J Nutr. 2005;135(9):2206-2211. View Abstract
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14. Wang, Q., Qiu, L., Chen, X. R., et al. Inhibitory effects of phloridzin dihydrate on the activity of mushroom (Agaricus bisporus) tyrosinase. Bioorg.Med Chem 2-1-2007;15(3):1568-1571. View Abstract
15. Zhao, H., Yakar, S., Gavrilova, O., et al. Phloridzin improves hyperglycemia but not hepatic insulin resistance in a transgenic mouse model of type 2 diabetes. Diabetes 2004;53(11):2901-2909. View Abstract