Background

• Raspberry ketone is a compound that is found in red raspberry fruits. It is responsible for the fruity aroma of raspberries, and it is often used as a fragrance and flavoring agent for cosmetics, perfumes, foods, and beverages. Although it is mostly found in raspberries, raspberry ketone has also been found in kiwifruit.
• Natural raspberry ketone is one of the most expensive yet popular flavoring agents in the food industry. However, because finding raspberry ketone in its natural form may be difficult, its synthetic preparation has been explored.
• There is some scientific evidence that suggests that raspberry ketone may improve the skin, promote hair growth and weight loss, and treat obesity. However, more research is needed to confirm the effects of raspberry ketone for any health-related purposes.

References

1. Beekwilder, J, van der Meer, IM, Sibbesen, O, et al. Microbial production of natural raspberry ketone. Biotechnol.J 2007;2(10):1270-1279. View Abstract
2. Feron, G, Mauvais, G, Martin, F, et al. Microbial production of 4-hydroxybenzylidene acetone, the direct precursor of raspberry ketone. Lett.Appl.Microbiol. 2007;45(1):29-35. View Abstract
3. Harada, N, Okajima, K, Narimatsu, N, et al. Effect of topical application of raspberry ketone on dermal production of insulin-like growth factor-I in mice and on hair growth and skin elasticity in humans. Growth Horm.IGF.Res 2008;18(4):335-344. View Abstract
4. Jang, EB, Casana-Giner, V, and Oliver, JE. Field captures of wild melon fly (Diptera: Tephritidae) with an improved male attractant, raspberry ketone formate. J Econ.Entomol. 2007;100(4):1124-1128. View Abstract
5. Keng-Hong, T and Nishida, R. Synomone or kairomone?--Bulbophyllum apertum flower releases raspberry ketone to attract Bactrocera fruit flies. J Chem.Ecol. 2005;31(3):497-507. View Abstract
6. Koeduka, T, Watanabe, B, Suzuki, S, et al. Characterization of raspberry ketone/zingerone synthase, catalyzing the alpha, beta-hydrogenation of phenylbutenones in raspberry fruits. Biochem.Biophys.Res Commun. 8-19-2011;412(1):104-108. View Abstract
7. Lin, CH, Ding, HY, Kuo, SY, et al. Evaluation of in Vitro and in Vivo Depigmenting Activity of Raspberry Ketone from Rheum officinale. Int.J Mol.Sci. 2011;12(8):4819-4835. View Abstract
8. Morimoto, C, Satoh, Y, Hara, M, et al. Anti-obese action of raspberry ketone. Life Sci. 5-27-2005;77(2):194-204. View Abstract
9. Ogawa, Y, Akamatsu, M, Hotta, Y, et al. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay. Bioorg.Med Chem.Lett. 4-1-2010;20(7):2111-2114. View Abstract
10. Park, KS. Raspberry ketone increases both lipolysis and fatty acid oxidation in 3T3-L1 adipocytes. Planta Med 2010;76(15):1654-1658. View Abstract
11. Pedapudi, S, Chin, CK, and Pedersen, H. Production and elicitation of benzalacetone and the raspberry ketone in cell suspension cultures of Rubus idaeus. Biotechnol.Prog. 2000;16(3):346-349. View Abstract
12. Shimoda, K, Harada, T, Hamada, H, et al. Biotransformation of raspberry ketone and zingerone by cultured cells of Phytolacca americana. Phytochemistry 2007;68(4):487-492. View Abstract
13. Ushiki, M, Ikemoto, T, and Sato, Y. Anti-obese activities of raspberry ketone. Aroma Research 2002;3(4):361.
14. Wang, L, Meng, X, and Zhang, F. Raspberry ketone protects rats fed high-fat diets against nonalcoholic steatohepatitis. J Med Food 2012;15(5):495-503. View Abstract
15. Zorn, H, Fischer-Zorn, M, and Berger, RG. A labeling study to elucidate the biosynthesis of 4-(4-hydroxyphenyl)-butan-2-one (raspberry ketone) by Nidula niveo-tomentosa. Appl.Environ.Microbiol. 2003;69(1):367-372. View Abstract