Background
- Sanghuang (Phellinus linteus) is a medicinal mushroom that has reportedly been used in Asian countries for centuries for a variety of ailments, including inflammation, gastrointestinal problems, and cancer.
- Although human clinical trials are lacking, sanghuang has been used to treat cancer in a few cases. In preliminary research, sanghuang has been shown to reduce tumor size, prevent metastasis in a variety of cancers, and enhance the beneficial effects of several anticancer drugs when used in combination therapy.
References
- Chen, W., He, F. Y., and Li, Y. Q. The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells. J Ethnopharmacol. 4-21-2006;105(1-2):280-285. View Abstract
- Choi, Y. H., Yan, G. H., Chai, O. H., et al. Inhibition of anaphylaxis-like reaction and mast cell activation by water extract from the fruiting body of Phellinus linteus. Biol Pharm.Bull. 2006;29(7):1360-1365. View Abstract
- Choi, S. B., Park, C. H., Choi, M. K., et al. Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats. Biosci.Biotechnol.Biochem. 2004;68(11):2257-2264. View Abstract
- Hur, J. M., Yang, C. H., Han, S. H., et al. Antibacterial effect of Phellinus linteus against methicillin-resistant Staphylococcus aureus. Fitoterapia 2004;75(6):603-605. View Abstract
- Kim, G. Y., Lee, J. Y., Lee, J. O., et al. Partial characterization and immunostimulatory effect of a novel polysaccharide-protein complex extracted from Phellinus linteus. Biosci.Biotechnol.Biochem. 2006;70(5):1218-1226. View Abstract
- Kim, G. Y., Choi, G. S., Lee, S. H., et al. Acidic polysaccharide isolated from Phellinus linteus enhances through the up-regulation of nitric oxide and tumor necrosis factor-alpha from peritoneal macrophages. J Ethnopharmacol. 2004;95(1):69-76. View Abstract
- Lee, H. J., Lee, H. J., Lim, E. S., et al. Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol Pharm.Bull. 2005;28(1):27-31. View Abstract
- Lee, Y. S., Kang, Y. H., Jung, J. Y., et al. Inhibitory constituents of aldose reductase in the fruiting body of Phellinus linteus. Biol Pharm.Bull. 2008;31(4):765-768. View Abstract
- Lim, B. O., Jeon, T. I., Hwang, S. G., et al. Phellinus linteus grown on germinated brown rice suppresses IgE production by the modulation of Th1/Th2 balance in murine mesenteric lymph node lymphocytes. Biotechnol.Lett. 2005;27(9):613-617. View Abstract
- Matsuba, S., Matsuno, H., Sakuma, M., et al. Phellinus linteus Extract Augments the Immune Response in Mitomycin C-Induced Immunodeficient Mice. Evid.Based.Complement Alternat.Med 2008;5(1):85-90. View Abstract
- Nam, S. W., Han, J. Y., Kim, J. I., et al. Spontaneous regression of a large hepatocellular carcinoma with skull metastasis. J Gastroenterol.Hepatol. 2005;20(3):488-492. View Abstract
- Park, I. H., Chung, S. K., Lee, K. B., et al. An antioxidant hispidin from the mycelial cultures of Phellinus linteus. Arch.Pharm.Res 2004;27(6):615-618. View Abstract
- Shibata, Y., Kashiwagi, B., Arai, S., et al. Administration of extract of mushroom Phellinus linteus induces prostate enlargement with increase in stromal component in experimentally developed rat model of benign prostatic hyperplasia. Urology 2005;66(2):455-460. View Abstract
- Song, Y. S., Kim, S. H., Sa, J. H., et al. Anti-angiogenic, antioxidant and xanthine oxidase inhibition activities of the mushroom Phellinus linteus. J Ethnopharmacol. 2003;88(1):113-116. View Abstract
- Zhu, T., Kim, S. H., and Chen, C. Y. A medicinal mushroom: Phellinus linteus. Curr Med Chem 2008;15(13):1330-1335. View Abstract