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Tin (Sn)

Background

  • Tin is a metallic element that forms alloys with other metals, conferring strength and hardness. It is relatively scarce and is not currently mined in the United States.
  • Inorganic tin compounds are used in toothpaste, perfumes, processed foods, and soaps. Organic tin compounds are used in plastics, pesticides, paints, wood preservatives, and rodent repellants. In general, organic tin compounds are the product of human activities and do not occur in nature.
  • The U.S. Food and Drug Administration (FDA) has not established a recommended dietary allowance (RDA) for tin. Tin is an ultratrace element in humans. It has been suggested that the amount of tin found in a healthy diet should be the value used to describe appropriate intake. Tin deficiency has been described in animals, but not in humans.
  • Daily intakes of tin from air, food, and water are small. The natural content of tin in plant and animal tissues is low. Tin is present in natural water only in trace amounts. Diet is the primary source of tin in humans. The main source of dietary tin is foods that have been stored in tin-lined cans.
  • Fluoride prevents cavities due to antibacterial and mineralization properties. Stannous fluoride (tin fluoride) has been used as a vehicle for fluoride in toothpastes and mouthwashes since the 1950s.
  • Occupational exposure to some forms of tin may cause lung disease, stomach cancer, and organ damage.

References

  • Aschner M, Gannon M, Kimelberg HK. Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium, L-glutamate and D-aspartate. Brain Res 1992;582(2):181-5.
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  • Blunden S, Wallace T. Tin in canned food: a review and understanding of occurrence and effect. Food Chem Toxicol 2003;41(12):1651-62.
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  • Caussy D, Gochfeld M, Gurzau E, et al. Lessons from case studies of metals: investigating exposure, bioavailability, and risk. Ecotoxicol Environ Saf 2003;56(1):45-51.
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  • Chang LW. The neurotoxicology and pathology of organomercury, organolead, and organotin. J Toxicol Sci 1990;Suppl 4:125-51.
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  • Feng X, Chen X, Cheng R, et al. Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent 2010;23 Spec No B:27B-31B.
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  • Funk JA, Gohlke J, Kraft AD, et al. Voluntary exercise protects hippocampal neurons from trimethyltin injury: Possible role of interleukin-6 to modulate tumor necrosis factor receptor-mediated neurotoxicity. Brain Behav Immun 2011 Mar 22. [Epub ahead of print].
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  • Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc 2006;137(12):1649-57.
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  • Marinova G. [Problems of interrupted pregnancy among working women]. Akush Ginekol (Sofiia) 1978;17(6):412-7.
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  • Niederman R. Stannous fluoride toothpastes reduce the gingival index more than sodium fluoride toothpastes. Evid Based Dent 2007;8(3):74-5.
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  • Nielsen FH. How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? J Nutr 1996;126(9 Suppl):2377S-2385S.
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  • Paraskevas S, van der Weijden GA. A review of the effects of stannous fluoride on gingivitis. J Clin Periodontol 2006 Jan;33(1):1-13.
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  • Rüdel H. Case study: bioavailability of tin and tin compounds. Ecotoxicol Environ Saf 2003;56(1):180-9.
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  • Stephen KW. The value of anti-caries and anti-plaque dentifrices at a community level. Adv Dent Res 1995;9(2):127-8.
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  • Thrash WJ, Dodds MW, Jones DL. The effect of stannous fluoride on dentinal hypersensitivity. Int Dent J 1994;44(1 Suppl 1):107-18.
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  • Winship KA. Toxicity of tin and its compounds. Adverse Drug React Acute Poisoning Rev 1988;7(1):19-38.
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Disclaimer: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.