- Transfer factor is defined as a substance in white blood cells that can transfer immunity from an immune or sensitized person to a nonimmune or nonsensitized individual. White blood cells are lysed, or burst, and the contents are processed into a tablet or injection. A skin test can be carried out to learn whether immunity has been transferred from one person to the other. The structure and mechanism of action of transfer factor are unknown.
- Transfer factor may be made from blood cells of normal healthy people, from individuals who been infected with a virus, such as herpes, or from individuals who are long-time survivors of specific diseases, such as bone cancer.
- Transfer factor has been used to treat a variety of conditions, including cancer, infections, and immune system disorders. High quality evidence supporting the use of transfer factor for any condition in humans is currently unavailable.
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Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
- Corrado F, Pizza G, de Vinci C, et al. [Immunotherapy with transfer factor in hormone-resistant metastasized carcinoma of the prostate]. Arch Esp Urol 1989; 42 Suppl 2:191-6. View Abstract
- Espinosa Padilla SE, Orozco S, Plaza A, et al. [Effect of transfer factor on treatment with glucocorticoids in a group of pediatric patients with persistent moderate allergic asthma] Revista alergia Mexico 2009;56(3): 67-71. View Abstract
- Göring HD, Ott D, Schwalm I, et al. [Cellular immune defect and transfer factor therapy in epidermolysis bullosa simplex of the Weber-Cockayne type]. Dermatologische Monatschrift [Dermatol Monatsschr] 1988;174 (1):10-3. View Abstract
- Hana I, Vrubel J, Pekarek J, et al. The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections. Biotherapy 1996; 9(1-3):91-5. View Abstract
- Iseki M, Aoyama T, Koizumi Y, et al. [Effects of transfer factor on chronic hepatitis B in childhood]. KansenshÅgaku Zasshi. The Journal Of The Japanese Association For Infectious Diseases [Kansenshogaku Zasshi] 1989;63 (12):1329-32. View Abstract
- Mastromatteo V, Negri L, Pacchioni D, et al. [Effects of transfer factor on the number of circulating lymphocytes in patients with spinocellular carcinoma of the cervicofacial area]. Boll Soc Ital Biol Sper 1987;63(11):1043-50. View Abstract
- Metzner G, Fricke HJ, Schröder D, et al. [Human transfer factor. II. Clinical results with the large pool transfer factor]. Folia Haematol Int Mag Klin Morphol Blutforsch 1983;110 (4):526-39. View Abstract
- Negri L, Pacchioni D, Calabrese F, et al. [Changes in circulating lymphocytes and "E" rosettes in patients with colonic neoplasms treated with transfer factor]. Bollettino Della Società Italiana Di Biologia Sperimentale [Boll Soc Ital Biol Sper] 1987;63(11): 1051-8. View Abstract
- Orozco TT, Solano MO, Sandoval G, et al. [Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. Rev Alerg Mex 2004;51(4):151-4. View Abstract
- Paganelli R, Soothill JF, Marshall WC, et al. Transfer factor and cytomegalovirus viruia. Lancet 1981;8214:273-4). View Abstract
- Pilotti V, Mastrorilli M, Pizza G, et al. Transfer factor as an adjuvant to non-small cell lung cancer (NSCLC) therapy. Biotherapy 1996;9(1-3): 117-21. View Abstract
- Sosa M, Flores G, Estrada S, et al. [Comparative treatment between thalidomide and transfer factor in severe atopic dermatitis]. Rev Alerg Mex 2001;48(2):56-64. View Abstract
- Simko M, Mokrán V, Nyulassy S. [Immunomodulatory therapy of epilepsy with transfer factor]. Bratisl Lek Listy 1997; 98(4):234-7. View Abstract
- Valdés Sánchez AF, Fernández Ortega C, Gómez EcheverrÃa AH, et al. [Atopic dermatitis. Treatment with transfer factor. A controlled clinical trial]. Rev Alerg 1991;38(6):158-62). View Abstract
- Wagner G, Knapp W, Gitsch E, et al. Transfer factor for adjuvant immunotherapy in cervical cancer. Cancer Detect Prev Suppl 1987;1:373-6. View Abstract
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