- Wild indigo (Baptisia australis) has deep blue to violet flowers, similar to sweet pea flowers. When the plant's sap is exposed to air, it turns purple. Although this sap has been used for dying, it is not as colorfast as true indigo (Indigofera tinctoria). Some Native Americans tribes used a tea of blue indigo root as an emetic (induces vomit) and purgative.
- Wild indigo is considered toxic and is on the U. S. Food and Drug Administration's (FDA) list of toxic plants. However, two studies in humans found no adverse effects when it was used in a combination of Baptisiae tinctoriae radix, Echinaceae pallidae/purpureae radix, and Thujae occidentalis herba. Currently, wild indigo seems most promising as an immunomodulator, as both laboratory studies and clinical studies using combination products have noted some benefit. However, more studies are needed using wild indigo as a monotherapy before its safety and efficacy can be determined.